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The type‐VII ESX‐1 secretion apparatus, encoded by the esx‐1 genetic locus, is essential for the export of EsxA and EsxB, two major virulence factors of Mycobacterium tuberculosis. ESX‐1 also requires the products of the unlinked espACD operon for optimal function and these proteins are considered integral parts of the secretion apparatus. Here we show that the espACD operon is not necessary for the...
The human pathogen Mycobacterium tuberculosis requires the ESX‐1 secretion system for full virulence. EspR plays a key role in ESX‐1 regulation via direct binding and transcriptional activation of the espACD operon. Here, we describe the crystal structures of EspR, a C‐terminally truncated form, EspRΔ10, as well as an EspR–DNA complex. EspR forms a dimer with each monomer containing an N‐terminal...
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