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The role of the peripheral sequence neighboring the core cross-β region was investigated using a peptide library constructed with all possible combinations of Lys, Glu, Ser, and Leu at three residue positions (X1–X3) forming the N-terminal region linked to the amyloid core sequence of the barnase-derived segment (A4–K22). By means of CD spectra and thioflavin T binding assay for 64 peptides, not only...
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