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Background: Nitric oxide (·NO) is used in biology as both an intercellular signaling agent and a cytotoxic agent. In signaling, submicromolar quantities of ·NO stimulate the soluble isoform of guanylate cyclase (sGC) in the receptor cell. ·NO increases the V max of this heterodimeric hemoprotein up to 400-fold by interacting with the heme moiety of sGC to form a 5-coordinate complex. Carbon...
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