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Two preparations of dimeric BS RNase - native and recombinant proteins caused identical immunosuppressive effects on MLC-stimulated human lymphocytes. The monomers of RNase A and BS RNase were ten times less active. The inhibitory effect on MLC-stimmulation was followed by 90 % inhibition of cell-mediated lympholysis (CML) caused by BS RNase (10 μg/ml). This effect indicated that BS RNase suppressed...
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