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Background: Dopamine replacement therapy in PD has been associated with both behavioral addictions and dopamine addiction.
Objectives: To investigate potential association between l‐dopa induced neuropsychiatric fluctuations and addictions in PD.
Methods: A cohort of 102 patients with PD suffering from motor complications of l‐dopa treatment was prospectively analyzed. We evaluated dopamine addiction,...
Only a few years after the introduction of levodopa, the first descriptions of motor fluctuations and dyskinesia related to dopaminergic therapy appeared. In PD, attention turned to their management, that had dampened the euphoria of the “levodopa miracle.” It soon became clear that neuropsychiatric, autonomic, and sensory features also tend to develop fluctuations after chronic exposure to l‐dopa...
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