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A series of 2,3‐dihydrobenzo[b][1,4]dioxin‐ and indolealkylamine derivatives were synthesized and the target compounds were evaluated for their binding affinities at the 5‐HT1A receptor and serotonin transporter. Antidepressant‐like activities of the compounds were screened using the tail suspension and forced swim tests in mice. Preliminary results indicated that the target compounds exhibited high...
In this paper, we report the discovery and the synthesis of novel, potential antipsychotic piperidine‐2,6‐dione derivatives combining potent dopamine D2, D3 and serotonin 5‐HT1A, 5‐HT2A, 5‐HT2C receptor properties. We describe the structure–activity relationships that led us to the promising derivative: 1‐(4‐(4‐(6‐fluorobenzo[d]isoxazol‐3‐yl)piperidin‐1‐yl)butyl)‐4‐(4‐chlorophenyl)‐piperidine‐2,6‐dione...
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