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Background: The principal human estrogen, 17β-estradiol, is a potent stimulator of certain endocrine-dependent forms of breast cancer. Because human estrogenic 17β-hydroxysteroid dehydrogenase (type I 17β-HSD) catalyzes the last step in the biosynthesis of 17β-estradiol from the less potent estrogen, estrone, it is an attractive target for the design of inhibitors of estrogen production and tumor...
The apoenzyme of the human placental 17β-hydroxysteroid dehydrogenase (17β-HSD) and its complex with NADP + were prepared from two alternative procedures. The apoenzyme (Form I) has an absorption maximum at about 279 nm, and an absorption ratio at 280 and 260 nm of 1.65 ± 0.1; whereas the complex (Form II) has a broad absorption peak between 268-278 nm, and a 280 to 260 nm ratio of 1.1 ±...
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