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Purpose To study the self-association states of insulin degludec and insulin aspart alone and combined in pharmaceutical formulation and under conditions simulating the subcutaneous depot. Methods Formulations were made of 0.6 mM degludec at 3 and 5 Zn/6 insulin monomers, and 0.6 mM aspart (2 Zn/6 insulin monomers). Self-association was assessed using size-exclusion chromatography (SEC) monitored...
Purpose This study was conducted to assess the suitability of insulin analogs acylated by various cholic acid derivatives for use as basal insulin, and to test the most promising of these, LysB29(Nɛ-lithocholyl-γ-Glu) des(B30) human insulin (NN344) in pigs. Methods Circular dichroism spectroscopy and size-exclusion chromatography were used to explore the physicochemical properties of the analogs,...
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