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Graft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation where activated donor T cells attack the genetically disparate host cells. The main target organs of the T cells in GVHD are the skin, liver, and intestine. In order to explain why the lung, one of the barrier organs, is spared from the injury of effector T cells, we hypothesize that endothelial...
Dendritic cells (DCs) play a critical role in both the cellular and humoral immune response to tumor cells. The participation of co-stimulator molecules on DCs is of vital importance for full activation of T cells. Conventional tumor chemotherapy cannot only induce apoptosis of malignant cells, but also do harm to benign DCs. Expression levels of co-stimulatory molecules (especially CD80 and CD86)...
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