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Liposomes are widely used in the biological field due to their good biocompatibility and surface modification properties. With the development of biochemistry and material science, many liposome structures and their surface functional components have been modified and optimized one by one, pushing the liposome platform from traditional to functionalized and intelligent, which will better satisfy and...
Bispecific antibodies possess exceptional potential as therapeutic agents due to their capacity to bind to two different antigens simultaneously. However, challenges pertain to unsatisfactory stability, manufacturing complexity, and limited tumor penetration hinder their broad applicability. In this study, a versatile technology is presented for the rapid generation of bispecific nanobody‐aptamer...
Developing efficient, robust, and cost‐effective trifunctional catalysts for the hydrogen evolution reaction (HER), oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) at high current density and high temperature is crucial for water splitting at industry‐level conditions and ultra‐high‐temperature Zinc‐air battery (ZAB). Herein, cobalt nanoparticles well‐integrated with nitrogen‐doped...
T‐Nb2O5 characterized by the pronounced intercalation pseudocapacitance effect, is regarded as a promising and alternative anode for fast‐charging Li‐ion batteries. However, its electrochemical kinetics are still hindered by the absence of sufficient and homogenous conductive wiring inside active microparticles. Herein, an in situ pillaring strategy of electronic nano‐wires is proposed to slice T‐Nb...
In future information storage and processing, magnonics is one of the most promising candidates to replace traditional microelectronics. Yttrium iron garnet (YIG) films with perpendicular magnetic anisotropy (PMA) have aroused widespread interest in magnonics. Obtaining strong PMA in a thick YIG film with a small lattice mismatch (η) has been fascinating but challenging. Here, a novel strategy is...
Osteoarthritis (OA) is a typical joint degenerative disease that is prevalent worldwide and significantly affects the normal activities of patients. Traditional treatments using diclofenac (DCF) as an anti‐inflammatory drug by oral administration and transdermal delivery have many inherent deficiencies. In this study, a lubricating microneedles (MNs) system for the treatment of osteoarthritis with...
A simple, reliable method for identifying β‐lactoglobulin (β‐LG) in dairy products is needed to protect those with β‐LG allergies. A common, practical strategy for target detection is designing simplified nucleic acid nanodevices by integrating functional components. This work presents a label‐free modular β‐LG aptasensor consisting of an aptamer‐loop G‐quadruplex (G4), the working conformation of...
In inverted perovskite solar cells, conventional planar 2D/3D perovskite heterojunctions typically exhibit a type‐II band alignment, where the electric field tends to drive the electron motion in the opposite direction to the direction of electron transfer. Here, a 2D/3D gradient heterojunction is developed by allowing the 2D perovskite to infiltrate the 3D perovskite surface along the grain boundaries...
Conventional photodynamic therapy (PDT) of rheumatoid arthritis (RA) faces a dilemma: low‐power is insufficient to kill pro‐inflammatory cells while high‐power exacerbates inflammation. Herein, mitochondrial targeting is introduced in PDT of RA to implement a “less‐is‐more” strategy, where higher apoptosis in pro‐inflammatory cells are achieved with lower laser power. In arthritic rats, chlorine 6‐loaded...
Intrinsic or acquired radioresistance remained an important challenge in the successful management of cancer. Herein, a novel “smart” multifunctional copper‐based nanocomposite (RCL@Pd@CuZ) to improve radiotherapy (RT) sensitivity is designed and developed. In this nanoplatform, DSPE‐PEG‐RGD modified on the liposome surface enhanced tumor targeting and permeability; capsaicin inserted into the phospholipid...
Smart Contact Lens
In article number 2309785, Weihua Pei, Kai Jiang, La Li, Guozhen Shen, and co‐workers present a Ti3C2Tx MXene‐based contact lens sensor with an extremely high sensitivity of 7.483 mV mmHg−1, which is then integrated with the wireless module and achieve real‐time intraocular pressure monitoring and warning via mobile phones. This work provides a new material platform and new thoughts...
The development of novel method for drug‐resistant bacteria detection is imperative. A simultaneous dual‐gene Test of methicillin‐resistant Staphylococcus aureus (MRSA) is developed using an Argonaute‐centered portable biosensor (STAR). This is the first report concerning Argonaute‐based pathogenic bacteria detection. Simply, the species‐specific mecA and nuc gene are isothermally amplified using...
Balancing the rigid backbones and flexible side chains of light‐harvesting materials is crucially important to reach optimized intermolecular packing, micromorphology, and thus photovoltaic performance of organic solar cells (OSCs). Herein, based on a distinctive CH‐series acceptor platform with 2D conjugation extended backbones, a series of nonfullerene acceptors (CH‐6F‐Cn) are synthesized by delicately...
Nanomaterials with biomimetic catalytic abilities have attracted significant attention. However, the stereoselectivity of natural enzymes determined by their unique configurations is difficult to imitate. In this work, a kind of chiral CuxCoyS‐CuzS nanoflowers (L/D‐Pen‐NFs) is developed, using porous CuxCoyS nanoparticles (NPs) as stamens, CuzS sheets as petals, and chiral penicillamine as surface...
The active lithium loss of lithium‐ion batteries can be well addressed by adding a cathode lithium compensation agent. Due to the poor conductivity and electrochemical activity, lithium carbonate (Li2CO3) is not considered as a candidate. Herein, an effective cathode lithium compensation agent, the recrystallized Li2CO3 combined with large specific surface area disordered porous carbon (R‐LCO@SPC)...
The electrocatalytic nitrite/nitrate reduction reaction (eNO2RR/eNO3RR) offer a promising route for green ammonia production. The development of low cost, highly selective and long‐lasting electrocatalysts for eNO2RR/eNO3RR is challenging. Herein, a method is presented for constructing Cu3P‐Fe2P heterostructures on iron foam (CuFe‐P/IF) that facilitates the effective conversion of NO2− and NO3− to...
Dual‐engineering involved of grain boundaries (GBs) and oxygen vacancies (VO) efficiently engineers the material's catalytic performance by simultaneously introducing favorable electronic and chemical properties. Herein, a novel SnO2 nanoplate is reported with simultaneous oxygen vacancies and abundant grain boundaries (V,G‐SnOx/C) for promoting the highly selective conversion of CO2 to value‐added...
With the rapid development and increasing popularity of electric vehicles and wearables, battery safety has become a leading focus in the field of energy storage research. Specifically, aluminum‐ion batteries are gaining increasing attention as low‐cost energy‐storage systems with high safety levels and theoretical energy density. However, the dense alumina passivation layer on the aluminum anode...
Modulating the coordination configuration of single Fe atom has been an efficient strategy to strengthen the redox dynamics for lithium‐sulfur batteries (LSBs) but remains challenging. Herein, the single Fe atom is functioned with nitrogen and carbon atoms in the first shell, and simultaneously, oxidized sulfur (─SOx) in the second shell, which presents a lower antibonding state and well address the...
Due to the relatively low photoluminescence quantum yield (PLQY) and horizontal dipole orientation of doped films, anthracene‐based fluorescent organic light‐emitting diodes (F‐OLEDs) have faced a great challenge to achieve high external quantum efficiency (EQE). Herein, a novel approach is introduced by incorporating penta‐helicene into anthracene, presented as linear‐shaped 3‐(4‐(10‐phenylanthracen‐9‐yl)phenyl)dibenzo[c,g]phenanthrene...