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The ankyrin repeat is an abundant, 33 residue sequence motif that forms a consecutive β-hairpin-helix-loop-helix (β2α2) fold. Most ankyrin repeat proteins consist of four or more complete repeats, which provide stabilizing interactions between adjacent modules. The cyclin-dependent kinase inhibitor and tumor suppressor p16INK4 (p16) is one of the smallest ankyrin repeat proteins with a known structure...
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