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Penicilliols A (1) and B (2) are novel 5-methoxy-3(2H)-furanones isolated from cultures of a fungus (Penicillium daleae K.M. Zalessky) derived from a sea moss, and their structures were determined by spectroscopic analyses. These compounds selectively inhibited activities of eukaryotic Y-family DNA polymerases (pols) (i.e., pols η, ι and κ), and compound 1 was a stronger inhibitor than compound 2...
Humans possess four Y-family polymerases: pols η, ι, κ and the Rev1 protein. The pivotal role that polη plays in protecting us from UV-induced skin cancers is unquestioned given that mutations in the POLH gene (encoding polη), lead to the sunlight-sensitive and cancer-prone xeroderma pigmentosum variant phenotype. The roles that pols ι, κ and Rev1 play in the tolerance of UV-induced DNA damage is,...
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