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Background Calicheamicins (CAL) are enedyine natural products with potent antibiotic and cytotoxic activity, used in anticancer therapy. The O-methyltransferase CalO6 is proposed to catalyze methylation of the hydroxyl moiety at the C2 position of the orsellinic acid group of CAL. Results Crystals of CalO6 diffracted non-isotropically, with the usable data extending to 3.4 Å. While no single method...
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