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Bone marrow stromal cells (MSCs) are being evaluated as a cellular therapeutic for immune-mediated diseases. We investigated the effects of MSCs in mice with chemically induced colitis and determined the effects of CD11b + cells based on the hypothesis that MSCs increase numbers of regulatory T cells.Colitis was induced in mice using trinitrobenzene sulfonic acid; symptoms were monitored as...
Background & Aims: Proteases play key roles in the pathogenesis of tumor growth and invasion. This study assesses the expression of cathepsin B in dysplastic adenomatous polyps. Methods: Aged ApcMin/+ mice served as an experimental model for familial adenomatous polyposis. The 4 experimental groups consisted of (a) animals injected with a novel activatable, cathepsin B sensing near infrared fluorescence...
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