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Cue‐induced drug seeking progressively increases over time of withdrawal from drug self‐administration in rats, a phenomenon called ‘incubation of craving’. The underlying mechanisms have been linked to increased expression of brain‐derived neurotrophic factor and GluR2‐lacking AMPA receptors in the mesolimbic dopamine (DA) system and also to increased extracellular signal‐regulated kinase activation...
The dopamine (DA) D3 receptor is posited to be importantly involved in drug reward and addiction, and D3 receptor antagonists have shown extraordinary promise as potential anti‐addiction pharmacotherapeutic agents in animal models of drug addiction. SB‐277011A is the best characterized D3 receptor antagonist in such models. However, the potential use of SB‐277011A in humans is precluded by pharmacokinetic...
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