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DNA is believed to be the primary target for many metal-based drugs. For example, platinum-based anticancer drugs can form specific lesions on DNA that induce apoptosis. New platinum drugs can be designed that have novel modes of interaction with DNA, such as the trinuclear platinum complex BBR3464. Also it is possible to design inert platinum(IV) pro-drugs which are non-toxic in the dark, but lethal...
There is much current interest in the design of metal compounds as drugs and diagnostic agents and in understanding the molecular mechanisms of action of metallopharmaceuticals already in clinical use. Central to progress in this area is investigation of the speciation of metal compounds, especially in biological media such as cells, body fluids and cell culture media. Modern multinuclear NMR approaches...
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