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A positron emission tomography (PET) probe with ultra-high specific radioactivity (SA) enables measuring high receptor specific binding in brain regions by avoiding mass effect of the PET probe itself. It has been reported that PET probe with ultra-high SA can detect small change caused by endogenous or exogenous ligand. Recently, Kealey et al. developed [11C]BU99008, a more potent PET probe for I...
The functions of I 2 -imidazoline receptors (I 2 Rs) are unknown, but evidence exists for their involvement in various neuropsychiatric disorders. Although a few positron emission tomography (PET) I 2 R ligands have been developed, of which [ 11 C]FTIMD and [ 11 C]BU99008 were evaluated as PET I 2 R imaging ligands in monkeys, no human PET imaging study...
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