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To further explore an efficient modified route for the shift from an antibacterial fluoroquinolone to an antitumor one, mono-Schiff bases 6a–6h related to ciprofloxacin C3 carbonylhydrazone and bis-Schiff bases 4a–4h corresponding to C3/C7 carbonylhydrazone/hydrazone attached on a skeleton of ciprofloquinolone were designed and synthesized, and their in vitro antitumor activity against CHO, HL60,...
To further expand an effective modified route for the shift from an antibacterial fluoroquinolone (FQ) to an antitumor FQ, two series of title compounds based on an isostere of the FQ C3 carboxylic group with two fused heterocyclic rings, [1,2,4]triazolo[3,4-b][1,3,4]thiadiazine and pyrazolo[5,1-c][1,2,4]triazole, respectively, were designed and synthesized starting from the current antibacterial...
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