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Neutrophil Mechanophenotyping
The intrinsic biophysical states of neutrophils are often associated with immune dysfunctions. In article number 2104822, Han Wei Hou and co‐workers report an “optics‐free” microfluidic biophysical cytometer for impedance‐based single cell electro‐mechano‐phenotyping. The developed platform integrates elasto‐inertial focusing, hydrodynamic cell pinching, and multifrequency...
The intrinsic biophysical states of neutrophils are associated with immune dysfunctions in diseases. While advanced image‐based biophysical flow cytometers can probe cell deformability at high throughput, it is nontrivial to couple different sensing modalities (e.g., electrical) to measure other critical cell attributes including cell viability and membrane integrity. Herein, an “optics‐free” impedance‐deformability...
Extracellular vesicles (EVs) are recognized as next generation diagnostic biomarkers due to their disease‐specific biomolecular cargoes and importance in cell–cell communications. A major bottleneck in EV sample preparation is the inefficient and laborious isolation of nanoscale EVs (≈50–200 nm) from endogenous proteins in biological samples. Herein, a unique microfluidic platform is reported for...
Extracellular Vesicle Isolation
Extracellular vesicles (EVs) are cell‐derived nanovesicles (≈5–200 nm) which play important roles in intercellular communication. In article number 2104470, Han Wei Hou and co‐workers report a low‐cost microfluidic size exclusion chromatography (μSEC) platform integrated with an on‐chip nanoliter sample plug injector for direct EV isolation from human plasma. Its portable...
Non‐invasive and real‐time monitoring of microcarriers and three‐dimensional cell cultures are important in biomanufacturing and bioprocesses. In article number 2007500, Han Wei Hou and co‐workers introduce a low‐cost microfluidic impedance cytometer with Field's metal electrodes for label‐free and continuous‐flow monitoring of spheroids/microcarriers based on changes in impedance signatures. Potential...
3D cellular spheroids/microcarriers (100 µm–1 mm) are widely used in biomanufacturing, and non‐invasive biosensors are useful to monitor cell quality in bioprocesses. In this work, a novel microfluidic approach for label‐free and continuous‐flow monitoring of single spheroid/microcarrier (hydrogel and Cytodex) based on electrical impedance spectroscopy using co‐planar Field's metal electrodes is reported...
Exogenous sources of amino acids are essential nutrients to fuel cancer growth. Here, the increased demand for amino acid displayed by cancer cells is unconventionally exploited as a design principle to replete cancer cells with apoptosis inducing nanoscopic porous amino acid mimics (Nano‐PAAM). A small library consisting of nine essential amino acids nanoconjugates (30 nm) are synthesized, and the...
An ultrathin planar cavity metasurface is proposed based on ultrathin film interference and its practicability for light manipulation in visible region is experimentally demonstrated. Phase of reflected light is modulated by finely adjusting the thickness of amorphous silicon (a‐Si) by a few nanometers on an aluminum (Al) substrate via nontrivial phase shifts at the interfaces and interference of...
Neutrophil dysfunction is strongly linked to type 2 diabetes mellitus (T2DM) pathophysiology, but the prognostic potential of neutrophil biomarkers remains largely unexplored due to arduous leukocyte isolation methods. Herein, a novel integrated microdevice is reported for single‐step neutrophil sorting and phenotyping (chemotaxis and formation of neutrophil extracellular traps (NETosis)) using small...
Rapid neutrophil profiling using a drop of blood is imperative for point‐of‐care risk stratification and precision medicine approaches in type 2 diabetes mellitus. In article number 1702832, Bernhard O. Boehm, Han Wei Hou, and co‐workers develop and clinically validate a novel integrated neutrophil purification and phenotyping (chemotaxis and formation of neutrophil extracellular traps (NETosis))...
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