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3,4‐Difluorobenzyl(1‐ethyl‐5‐(4‐((4‐hydroxypiperidin‐1‐yl)‐methyl)thiazol‐2‐yl)‐1H‐indol‐3‐yl)carbamate (NAI59), a small molecule with outstanding therapeutic effectiveness to anti‐pulmonary fibrosis, was developed as an autotaxin inhibitor candidate compound. To evaluate the pharmacokinetics and plasma protein binding of NAI59, a UPLC–MS/MS method was developed to quantify NAI59 in plasma and phosphate‐buffered...
Orientin showed a broad array of biological activities, and it is the major bioactive compound in the Trollius chinensis Bunge. The aim of this study was to investigate the comparative pharmacokinetics of orientin after intravenous administration of single orientin and T. chinensis Bunge extract. Sample preparation involved a simple one‐step deproteinization procedure with acetonitrile. Chromatographic...
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