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Angiogenesis is a key player in the pathogenesis of rheumatoid arthritis. Exocytosis from Weibel–Palade bodies is a prerequisite for angiopoietin‐2 (Ang‐2) to activate endothelial cells and initiate angiogenesis. Geniposide (GE) was previously reported to exert anti‐angiogenic effects. The aim of this study was to shed light on whether and how GE regulates Ang‐2 exocytosis. A rat model of adjuvant...