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A new signal-amplification strategy based on copper(II) (Cu2+)-dependent DNAzyme was developed for sensitive impedimetric biosensing of Cu2+ in aqueous solution by coupling with target-induced formation of hemin/G-quadruplex-based DNAzyme and enzymatic catalytic precipitation technique. Initially, the target analyte cleaved the Cu2+-specific DNAzyme to generate an initiator strand on the sensor. Thereafter,...
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