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Myeloid-derived suppressor cells (MDSCs), one of the main cell populations, are responsible for regulating the immune response, which accumulates in tumor-bearing mice and humans contributing to cancer development. Exosomes produced by tumor cells have been involved in tumor-associated immune suppression. However, the role of exosomes is unclear in the activation of MDSCs. Here, we have purified tumor-derived...
Glioma is the most common and aggressive tumor in human central nervous system. MMP-13 plays an important role in tumor aggressive process for it can degrade the extracellular matrix of basement membranes. The present study was to investigate the expression of MMP-13 in clinical glioma samples and its association with clinicopathological characteristics as well as survival of patients. Clinical glioma...
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