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The microcystin cyanobacterial hepatotoxins represent an increasingly severe global health hazard. Since microcystins are found world wide in drinking water reservoirs concern about the impact on human health has prompted investigations into remedial water treatment methods. This preliminary study investigates the scavenging from water of microcystin-LR by fine-grained particles known to have a high...
Over a period of 3 days saltwater mussels, Mytilus edulis, were fed a cyanobacteria, Microcystis aeruginosa, that contained a high concentration of microcystins. The mussels were killed on a periodic basis over the course of 2 months. Mussels were also collected at two sites were high levels of microcystins in tissues had been noted. A strategy based on the chemically unique nature of the C ...
The tissue distribution and clearance of radiolabeled microcystin-LR administered to Atlantic salmon via i.p. injection has been re-examined using uniformly 14 C-labeled toxin. Significant differences were found to exist between these results and those obtained when fish received an i.p. injection of tritium-labeled dihydromicrocystin-LR. In addition, MeOH liver extracts were assayed...
The two epimers of [ 3 H]dihydromicrocystin-LR (spec. act. 32.6 μCi/μmole) were synthesized by reduction of microcystin-LR, a cyclic heptapeptide hepatotoxin, with sodium boro[ 3 H]hydride. In Atlantic salmon, following an i.p. injection of the epimers (0.1 mg of toxin/100 g), the toxins were; after 2 hr, concentrated in the liver and pyloric caeca and intestine; after 5 and 22 hr,...
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