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Trinucleotide repeats (TNRs) expansion disorders are severe neurodegenerative and neuromuscular disorders that arise from inheriting a long tract (30–50 copies) of a trinucleotide unit within or near an expressed gene (Figure 1a). The mutation is referred to as ‘trinucleotide expansion’ since the number of triplet units in a mutated gene is greater than the number found in the normal gene. Expansion...
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