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We report the first remote flight control of an insect using microfabricated flexible neuroprosthetic probes (FNPs) that directly interface with the animal's central nervous system. The FNPs have a novel split-ring design that incorporates the anatomical bi-cylinder structure of the nerve cord and allows for an efficient surgical process for implantation (Figure 1a). Additionally, we have integrated...
To detect electrical properties of cells, we have developed a method called iso-dielectric separation (IDS), where cells are placed in a spatially varying electric field and a spatially varying conductivity gradient that forces them to the location in a channel where their net polarizability (p) is zero. At that location, the force on the cell, given by the dielectrophoretic force (F - p????E) will...
Electrical stimulation has been shown to improve functional assembly of cardiomyocytes in vitro for cardiac tissue engineering. Carbon electrodes were found in past studies to have the best current injection characteristics. The goal of this study was to develop rational experimental design principles for the electrodes and stimulation regime, in particular electrode configuration, electrode ageing,...
We present an architecture ideally suited for imaging and sorting large populations of single cells. Our approach combines wide-field, passive, hydrodynamic trapping of cells with active retrieval of specific single cells using radiation pressure and microfluidics. The architecture scales easily and offers single-cell resolution both with respect to imaging and manipulation, enabling sorts predicated...
Electrical stimulation has been shown to improve functional assembly of cardiomyocytes in vitro for cardiac tissue engineering. The goal of this study was to assess the conditions of electrical stimulation with respect to the electrode geometry, material properties and charge-transfer characteristics at the electrode-electrolyte interface. We compared various biocompatible materials, including nanoporous...
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