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In this paper, we describe two simple, label-free, homogenous assays using gold nanoparticles (Au NPs)—one to detect coagulation-related proteins and the other to screen inhibition reactions. The first nanosensor functions on the basis of the fact that thrombin catalyzes fibrinogen to form long-chain fibrins, which then induce aggregation of Au NPs. We applied this sensor to study the interactions...
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