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Liver transplant tissues offer the unique opportunity to model the longitudinal protein abundance changes occurring during hepatitis C virus (HCV)‐associated liver disease progression in vivo. In this study, our goal was to identify molecular signatures, and potential key regulatory proteins, representative of the processes influencing early progression to fibrosis. We performed global protein profiling...
Quantification of LC‐MS peak intensities assigned during peptide identification in a typical comparative proteomics experiment will deviate from run‐to‐run of the instrument due to both technical and biological variation. Thus, normalization of peak intensities across an LC‐MS proteomics dataset is a fundamental step in pre‐processing. However, the downstream analysis of LC‐MS proteomics data can...
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