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A novel class of nanoparticles is developed for the co‐delivery of a short cell penetrating peptide and a chemotherapeutic drug to achieve enhanced cytotoxicity. Tunable cytotoxicity is achieved through non‐toxic peptide‐facilitated gating. The strategy relies on a one‐step blending process from polymer building blocks to form monodisperse, PEGylated particles that are sensitive to cellular pH variations...
In der Natur ist die Aminosäuresequenz durch den genetischen Code festgelegt. Die Biosynthese von Polypeptiden durch Bakterien ermöglicht es, diesen natürlichen Prozess für eine exakte Kontrolle von Eigenschaften wie Molekulargewicht, chemische Funktionalität und Struktur zu nutzen. Es wird gezeigt, wie über die gezielte Positionierung funktioneller Gruppen die Zersetzung von Polypeptidpartikeln gesteuert...
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