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Previous research reported an age‐related decline in brain norepinephrine transporter (NET) using (S, S)‐[11C]O‐methylreboxetine ([11C]MRB) as a radiotracer. Studies with the same tracer have been mixed in regard to differences related to body mass index (BMI). Here, we investigated potential age‐, BMI‐, and gender‐related differences in brain NET availability using [11C]MRB, the most selective available...
Objective
Parkinson disease is characterized by motor and nonmotor symptoms, reduced striatal dopamine signaling, and loss of dopamine neurons in the substantia nigra. It is now known that the pathological process in Parkinson disease may begin decades before the clinical diagnosis and include a variety of neuronal alterations in addition to the dopamine system.
Methods
This study examined the...
The neurotransmitter dopamine is present in the retina and is involved in several modulatory functions. Unlike in rodents, dopamine D3 receptors are expressed in the retina of humans. Recently, uptake of the D3 receptor‐preferring radiotracer [11C]‐(+)‐PHNO has been observed in a retina‐like region of interest (ROI) in humans. Here, we attempted to quantify [11C]‐(+)‐PHNO uptake into this ROI using...
Objective
Brivaracetam (BRV) and levetiracetam (LEV) are antiepileptic drugs that bind synaptic vesicle glycoprotein 2A (SV2A). In vitro and in vivo animal studies suggest faster brain penetration and SV2A occupancy (SO) after dosing with BRV than LEV. We evaluated human brain penetration and SO time course of BRV and LEV at therapeutically relevant doses using the SV2A positron emission tomography...
We aimed to characterize changes in binding of (‐)‐[18F]Flubatine to α4β2*‐nicotinic acetylcholine receptors (α4β2*‐nAChRs) during a tobacco cigarette smoking challenge. Displacement of (‐)‐[18F]Flubatine throughout the brain was quantified as change in (‐)‐[18F]Flubatine distribution volume (VT), with particular emphasis on regions with low VT. Three tobacco smokers were imaged with positron emission...
Alcohol use and misuse is known to involve structural brain changes. Numerous imaging studies have examined changes in gray matter (GM) volumes in dependent drinkers, but there is little information on whether non‐dependent drinking is associated with structural changes and whether these changes are related to psychological factors—such as alcohol expectancy—that influence drinking behavior. We used...
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