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Non-peptide antagonists of the oxytocin receptor (OTR) have been developed to prevent pre-term labour. The benzoxazinone-based antagonists L-371,257 and L-372,662 display pronounced species-dependent pharmacology with respect to selectivity for the OTR over the V 1a vasopressin receptor. Examination of receptor sequences from different species identified Ala 318 in helix 7 of the human...
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