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SCO (synthesis of cytochrome c oxidase) proteins are involved in the assembly of the respiratory chain enzyme cytochrome c oxidase acting to assist in the assembly of the Cu A center contained within subunit II of the oxidase complex. The Cu A center receives electrons from the reductive substrate ferrocytochrome c, and passes them on to the cytochrome a center. Cytochrome a feeds...
The SCO protein from the aerobic bacterium Bacillus subtilis (BsSCO) is involved in the assembly of the cytochrome c oxidase complex, and specifically with the Cu A center. BsSCO has been proposed to play various roles in Cu A assembly including, the direct delivery of copper ions to the Cu A site, and/or maintaining the appropriate redox state of the cysteine ligands during...
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