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Sco is an accessory protein required for assembly of the Cu A center of cytochrome c oxidase. Functions proposed for Sco include as a copper chaperone and as a thiol–disulfide exchange protein. Differential scanning calorimetry (DSC) is used here to assess the interaction between the Bacillis subtilis version of Sco (BsSco) and Cu(II). When BsSco binds Cu(II) its melting temperature increases...
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