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The present studies investigate the hypothesis that the locus coeruleus-norepinephrine (LC-NE) system plays a role in the neural substrates underlying individual differences in behavioral reactivity to stress. Individuals were selected from a random sample of Sprague-Dawley rats and categorized as a high responder (HR), middle responder (MR), or low responder (LR) based on the initial locomotor response...
The locus coeruleus (LC) noradrenergic system is activated by a range of arousing and stressful stimuli. The serotonergic inputs to this structure have been shown to attenuate LC activation under some conditions. The present study examined the effect of fluoxetine, a selective serotonin reuptake inhibitor (SSRI) known to be a clinically effective antidepressant, on basal and stress-induced norepinephrine...
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