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Aims
To investigate the effects of a single dose of 1.2 mg liraglutide, a once‐daily glucagon‐like peptide‐1 (GLP‐1) receptor agonist, on key renal variables in patients with type 2 diabetes.
Methods
The study was a placebo‐controlled, double‐blind, crossover trial in 11 male patients with type 2 diabetes. Measurements included 51Cr‐EDTA plasma clearance estimated glomerular filtration rate (GFR)...
Several variants of the catechol-O-methyltransferase (COMT) gene have recently been linked to pain sensitivity. In the present study, electrophysiological field potential recordings from the dorsal horn in rats were used to examine the spinal effect of reduced COMT activity. The data demonstrated that 30mg/kg of the COMT inhibitor OR 486 reduced spinal nociceptive responses to painful stimuli (p≤0...
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