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Background: Pitrakinra is a recombinant protein derived from human interleukin‐4 (IL‐4) that binds to IL‐4Rα and acts as a competitive antagonist of IL‐4 and IL‐13. The studies reported here compare the dose‐ranging effects of pitrakinra on allergen‐induced airway hyperresponsiveness (AHR) and airway eosinophilia when administered subcutaneously (s.c.) or by inhalation to the Ascaris suum‐sensitive...
IPL576,092, a lead compound from a novel class of polyhydroxylated sterols, was tested in models of allergen-induced bronchoconstriction and airway inflammation. In a rat ovalbumin lung inflammation model, orally administered IPL576,092 significantly inhibited the challenge-mediated increase in total bronchoalveolar lavage leukocyte numbers, and macrophage and lymphocyte infiltration (1–10mg/kg/day)...
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