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To evaluate, posthoc, the relationship between serum total testosterone and response to therapy in a study of tadalafil once daily for erectile dysfunction (ED).Men were aged ≥18 years, with ≥3-month history of ED and partial prior response to on-demand (PRN) phosphodiesterase type 5 inhibitor (PDE5I) therapy. A 4-week maximum-dose PRN PDE5I run-in was followed by a 4-week nondrug washout period,...
The evaluation and treatment of hypogonadal men has become an important part of urologic practice. Fatigue, loss of libido, and erectile dysfunction are commonly reported, but nonspecific symptoms and laboratory verification of low testosterone (T) are an important part of evaluation in addition to a detailed history and physical examination. Significant intraindividual fluctuations in serum T levels,...
Because of many societal factors, the number of men over the age of 35 desiring to conceive children has increased over the past 40 years. The purpose of this review is to identify the mechanisms of aging on male fertility, to evaluate the genetic risk for the offspring, and to provide counseling for the older male. Most evidence suggests trends that increased paternal age has negative effects on...
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