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Alginate microspheres could serve as an ideal drug delivery platform for selective transcatheter administration of gemcitabine to pancreatic tumors. This study aimed to modify gemcitabine release with ultrasmall superparamagnetic iron oxide (USPIO) clusters. We tested the hypothesis that USPIOs will adsorb drug and slow drug release. Further, we hypothesized that drug release can be accelerated by...
The purpose was to compare induced changes within US, CT, and MRI images shortly after irreversible electroporation (IRE) ablation of normal liver parenchyma and hepatic tumors.All procedures were approved by IACUC. 48 rats were divided into 8 groups, 24 were implanted with N1-S1 tumors. US, CT, and MRI measurements were performed in both normal and tumor tissues pre/post-IRE. MRI was also performed...
Amonafide has demonstrated potent efficacy to treat a broad range of solid tumors including HCC but clinical application has been limited due to severe toxicities. These toxicities have been mitigated with a new metabolically stable drug, 6-methoxyenthylamino numonafide (MEAN). Local transcatheter delivery to liver tumors using drug-eluting beads could also reduce toxicity of this drug. We aimed to...
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