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5-Lipoxygenase (5-LO) has been suggested as a modulator of atherosclerotic plaque instability, however, its role in MMP production in vascular smooth muscle cells (VSMC) is still unclear. Thus, this study investigated the role of 5-LO in HNE-enhanced MMP-2 production in VSMC, and the mechanisms by which this enzyme could be activated by HNE. VSMC stimulated with HNE (1μM) produced MMP-2, which was...
Fasting plasma mevalonic acid (MVA), an index of cholesterol (C) synthesis, correlates closely with VLDL-apoB secretion in controls and patients with secondary hypertriglyceridaemia but not in familial hypercholesterolaemia. To investigate this further we studied normolipidaemic controls and subjects with primary type IIa and IIb phenotypes. As shown in the table LDL-C was raised in both types IIa...
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