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The catalytic activities of recombinant cytochrome P450s expressed in E. coli have been impeded by the absence of endogenous P450 reductase. To solve this problem, we coexpressed P450 reductase with CYP3A4. Membranes from this strain contained 215 pmol P450/mg protein and a reductase activity of 1315 nmol cytochrome c reduced/min per mg. We detected 6β-hydroxylation of testosterone and oxidation...
Drug metabolism influences the pharmaco-toxicological properties of a vast array of compounds and is controlled by a complex system of drug metabolizing enzymes. A thorough understanding of this system allows the more effective development of therapeutic drugs, as well as a significant improvement of risk assessment, particularly in the field of chemical carcinogenesis. The early identification...
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