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Murine gammaherpesvirus 68 (γHV68, MHV-68)-specific CD4 T cells control γHV68 infection by reducing the frequency of latently infected cells and by inhibiting viral replication. We have previously demonstrated that CD4 T cells do not require CD8 T or B cells to control γHV68 replication, demonstrating a helper-independent activity of CD4 T cells during γHV68 infection. The effector mechanism(s) required...
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