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Local anaesthetics potentiate epidural or intrathecal opioid analgesia via a poorly defined mechanism. In this study, we have examined the interaction of local anaesthetics (lidocaine, bupivacaine and its optical isomers, tetracaine, procaine and prilocaine) with recombinant μ-, κ-, and δ-opioid receptors expressed in Chinese hamster ovary cells (CHO-μ, κ, and δ, respectively). Lidocaine produced...
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