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BackgroundBMN 673 is a potent inhibitor of poly‐ADP ribose polymerase (PARP) that is in clinical testing with a primary focus on BRCA‐mutated cancers. BMN 673 is active both through inhibiting PARP catalytic activity and by tightly trapping PARP to DNA at sites of single strand breaks.
ProcedureBMN 673 was tested in vitro at concentrations ranging from 0.1 nM to 1 μM and in vivo at a daily dose of...
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