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Functional roles of ionic currents in a membrane delimited sino-atrial node (SAN) cell model were investigated. Ionic currents were blocked and intracellular calcium ([Ca2+]i) buffered to study their effects on action potential (AP) characteristics. The simulations revealed that blocking the hyperpolarization activated current and the T-type calcium current caused an increase of cycle length (CL)...
Cardiac rhythm is irregular with heart rate varies from time to time. Heart rate variation (HRV) is clinically relevant and indicative of a pathological condition. However, the mechanisms underlying the HRV are still controversial and stochastic nervous modulation may be a major responsible factor. In this study, we implemented a computer simulation study to investigate a causative link between stochastic...
Atrial fibrillation (AF) is commonly associated with rapid excitation of the atria, but mechanisms of its initiation are unknown. Intracellular Ca2+ dynamics has been shown to affect cell restitution properties and, as a result, patterns of rapid reentrant excitation in ventricles at early stages of ventricular fibrillation. We study effects of the intracellular Ca2+ concentration changes on restitution...
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