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To investigate complex electrophysiological behaviour (such as reentrant cardiac arrhythmias) in the setting of the complex anatomy of the heart, the use of a simplified model is computationally more effective. In this study, the Rogers-modified FitzHugh-Nagumo model was further modified to allow control of action potential upstroke velocity, conduction velocity, action potential duration and refractory...
Cardiac rhythm is irregular with heart rate varies from time to time. Heart rate variation (HRV) is clinically relevant and indicative of a pathological condition. However, the mechanisms underlying the HRV are still controversial and stochastic nervous modulation may be a major responsible factor. In this study, we implemented a computer simulation study to investigate a causative link between stochastic...
Atrial fibrillation (AF) is commonly associated with rapid excitation of the atria, but mechanisms of its initiation are unknown. Intracellular Ca2+ dynamics has been shown to affect cell restitution properties and, as a result, patterns of rapid reentrant excitation in ventricles at early stages of ventricular fibrillation. We study effects of the intracellular Ca2+ concentration changes on restitution...
The electrocardiogram (ECG) is an important index of clinical diagnosis of cardiac arrhythmias. Simulations of ECG had revealed the causative relationship between waveforms of ECG and action potentials (APs). However, those studies were mainly based on the Luo-Rudy (LRd) model or the Priebe-Beuckelman (PB) model. In this study, we developed a ID model of transmural ventricular strand based on the...
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