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Parkinson's disease and dementia with Lewy bodies are very frequent neurological disorders of the elderly. Mutations in the α-synuclein (αSYN) gene cause Parkinson's disease, often associated with dementia. Neuropathologically these diseases are characterized by the presence of Lewy bodies and Lewy neurites, intraneuronal inclusions mostly composed of αSYN protein fibrils. Moreover, αSYN is phosphorylated...
Mit steigender Lebenserwartung der Bevölkerung wird der Anteil an den Gesundheitskosten zunehmen, den die neurodegenerativen und demenziellen Erkrankungen verursachen. Neuere Entwicklungen, wie etwa die Entdeckung der Rolle von TDP-43 haben es möglich gemacht, die frontotemporalen Demenzen unter einem neuen Blickwinkel zu sehen und einen Zusammenhang mit der amyotrophen Lateralsklerose herzustellen...
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