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The Ca2+sensitivity of tension in cardiac muscle is length dependent, such that the sensitivity is diminished with decreasing sarcomere length below 2.4μm. This length dependence of Ca2+sensitivity of tension also forms the basis for the Frank–Starling mechanism in the heart. The fast-twitch skeletal muscle has a much lower length dependence of Ca2+sensitivity. In a recent study of skinned cardiotrabeculae,...
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