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Identification of G protein-coupled receptors and their specific function in a given neuron becomes essential to better understand the variety of signal transduction mechanisms associated with neurotransmission. We hypothesized that angiotensin II type 1 (AT 1 ) and dopamine D 2 receptors form heteromers in the central nervous system, specifically in striatum. Using bioluminescence...
Heteromerization of G-protein-coupled receptors is an important event as they integrate the actions of extracellular signals to give heteromer-selective ligand binding and signaling, opening new avenues in the development of potential drug targets in pharmacotherapy. The aim of the present paper was to check for cannabinoid CB1–GPR55 receptor heteromers in the central nervous system (CNS), specifically...
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