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Fatty acids (FA) regulate the expression of genes involved in lipid and energy metabolism. In particular, two transcription factors, sterol regulatory element binding protein-1c (SREBP-1 c) and peroxisome proliferator activated receptor α (PPARα), have emerged as key mediators of gene regulation by FA. SREBP-1 c induces a set of lipogenic enzymes in liver. Polyunsaturated fatty acids (PUFA), but not...
This review briefly examines the recent progress in knowledge about the synthesis and degradation of highly unsaturated fatty acids (HUFA) and their functions. Following the cloning of mammalian Δ6-desaturase (D6D), the D6D mRNA was found in many tissues, including adult brain, maternal organs, and fetal tissue, suggesting an active synthesis of HUFA in these tissues. The cloning also confirmed the...
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