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Large-scale gene expression studies in the mammalian brain offer the promise of understanding the topology, networks, and, ultimately, the function of its complex anatomy, opening previously unexplored avenues in neuroscience. High-throughput methods permit genome-wide searches to discover genes that are uniquely expressed in brain circuits and regions that control behavior. Previous gene expression...
Conventional cluster analysis of gene expression is often limited in its ability to incorporate cellular level heterogeneity that exists in the brain. We generate in situ hybridized gene expression cellular resolution maps (a set of multiple 2D images for each gene) of the mouse brain. Using a digital mouse brain atlas and advanced image analysis methods, gene expression profiles for each brain structure...
PET/CT imaging has introduced new challenges in accurate quantitation of lung nodules due to respiratory motion and mismatches in CT-based attenuation correction (CTAC). We used Monte Carlo simulations to investigate how respiratory-correlated CTAC can be optimized to account for mis-registration between the AC data and the PET data due to respiratory motion. This step also allows compensating for...
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